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Triamterene 50mg + Benzthiazide 25mg Salt Information :
Uses of Triamterene 50mg + Benzthiazide 25mg:
Triamterene + Benzthiazide combination belongs to thiazide diuretic and used to treat hypertension and mild to moderate oedema (Swelling).
Side Effects of Triamterene 50mg + Benzthiazide 25mg:
Photosensitivity reactions; increase in uric acid concentrations; megaloblastic anaemia; thrombocytopenia; hyperkalaemia; nephrolithiasis; renal failure; GI disturbances such as nausea, vomiting, diarrhoea; dry mouth; fatigue; dizziness; skin rash, muscle cramps; headache; orthostatic hypotension; increased BUN concentrations, LFT abnormalities.
Drug Interactions of Triamterene 50mg + Benzthiazide 25mg:
Increased risk of hyperkalemia with potassium supplements, other potassium-sparing diuretics, ACE inhibitors, angiotensin II receptor antagonists, trilostane, potassium-containing medications (such as parenteral penicillin G potassium), eplerenone, tacrolimus, ciclosporin, LMWH. Increased risk of bone marrow suppression with methotrexate. Potentially Fatal: Increased risk of nephrotoxicity with NSAIDs and ciclosporin. Increased risk of lithium toxicity.
Contraindications of Triamterene 50mg + Benzthiazide 25mg:
severe renal or hepatic impairment, preexisting or drug-induced hyperkalemia, patients at risk of respiratory or metabolic acidosis. Lactation.
Mechanism of Action of Triamterene 50mg + Benzthiazide 25mg:
Triamterene is a potassium sparing diuretic which appears to act mainly on the distal renal tubules. It increases the excretion of Na and reduces the excretion of potassium. It adds to the natriuretic but reduces the kaliuretic effects of other diuretics. It is structurally similar to folate and has anti-folate activity. Onset: Diuresis: 2-4 hr. Duration: Diuresis: 7-9 hr. Absorption: Rapid but variable absorption from GI tract. Bioavailability: 50%. Distribution: Crosses the placenta; may be distributed into breast milk. Protein binding: 60%. Metabolism: Extensively metabolised. Plasma half-life: 2 hr. Excretion: Mainly excreted in the urine as metabolites and unchanged triamterene.
Special Precautions for Triamterene 50mg + Benzthiazide 25mg:
Renal and hepatic impairment; cirrhosis; DM; hyponatraemia; hyperuricaemia; history of nephrolithiasis; depleted folic acid stores. Monitor electrolyte concentrations closely, especially potassium levels. Observe for signs of liver damage, blood dyscrasias or other idiosyncratic reactions. Discontinue treatment if urinary calculus is passed. Pregnancy and elderly.