Budamate-200 Trans Inhaler

Rs. 297.02 ( Lupin )
Budesonide 200mcg + Formoterol 6mcg
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Budamate-200 Trans Inhaler Price :Rs. 297.02

Budamate-200 Trans Inhaler Salt Information :

Side Effects of Budamate-200 Trans Inhaler:

Headache, nasopharyngitis, upper respiratory tract infections, stomach discomfort, vomiting, oral candidiasis, back pain, nasal congestion, sinusitis.

Drug Interactions of Budamate-200 Trans Inhaler:

Concomitant admin with CYP3A4 inhibitor e.g. itraconazole, clarithromycin, erythromycin may inhibit the metabolism of budesonide. Concurrent use with nonpotassium-sparing diuretics may lead to ECG changes and/or hypokalaemia.

Contraindications of Budamate-200 Trans Inhaler:

Primary treatment of status asthmaticus or other acute episodes of asthma.

Mechanism of Action of Budamate-200 Trans Inhaler:

Budesonide is a corticosteroid that has mainly glucocorticoid activity. It prevents and controls inflammation by controlling the rate of protein syntheis, decreasing the migration of polymorphonuclear leucocytes/fibroblasts and reversing capillary permeability. Formoterol fumarate is a selective β2-adrenergic agonist. It causes bronchodilation by catalysing the conversion of adenosine triphosphate to cyclic-3', 5'-adenosine monophosphate (cyclic AMP) resulting in bronchial smooth muscle relaxation. Absorption: Budesonide: Orally inhaled budesonide is rapidly absorbed in the lungs. Formoterol: Rapidly absorbed after inhalation. Distribution: Budesonide: 85-90% bound to plasma proteins. Metabolism: Formoterol: Primary metabolism pathway is via direct glucuronidation and O-demethylation followed by conjugation to inactive metabolites. Excretion: Budesonide: Excreted in urine and faeces as metabolites. Formoterol: Excreted mainly in urine and some in faces.

Special Precautions for Budamate-200 Trans Inhaler:

May increase the risk of death in patients. Not to be used for transferring patients from systemic corticosteroid treatment. May produce paradoxical bronchospasm which is life-threatening. Caution when used in patients with CV diseases, especially coronary insufficiency, cardiac arrhythmias and hypertension. Chronic use may further decrease bone mineral content when used in patients with advanced age, osteoporosis, poor nutrition, sedentary lifestyle or tobacco use. May reduce growth velocity when used in paediatric patients. Caution when used in patients with active or quiescent tuberculosis infection of the respiratory tract, untreated systemic fungal, bacterial, viral or parasitic infections, or ocular herpes simplex. Pregnancy and lactation.

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